Elias Gatos, M.D.
Surgeon Gynecologist – Obstetrician
Scientific Director emBIO Assisted Reproduction Unit

Zona pellucida measurement

What it is
This is a method to quantify the zona pellucida and determine the molecular constitution and density of the glycoprotein zone with a view to precisely calculating structural changes sustained by zona pellucida and further assess egg quality.

When to recommend it
During the first days of its development, the embryo is surrounded by a transparent zone protecting it. As the embryo develops, the zona pellucida changes and often hardens thus making normal hatching difficult. This is where assisted hatching intervenes, during which a hole is made in zona pellucida or the zona pellucida is made thinner using special micromanipulation techniques (laser).
The new Spindle View method helps us better understand changes occurring in zona pellucida and its structure.

The procedure at a glance
A zona pellucida measurement is performed in a friendly way, it reduces the likelihood for damage to it or embryos before their transfer and it provides significant knowledge and information helping us understand hatching and normal embryo development.


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